Yamaguchi Esterification - Jejaring Kimia


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November 15, 2015

Yamaguchi Esterification

Schematic of the Yamaguchi esterification. Reagents: carboxylic acid, Et3N, Yamaguchi reagent, DMAP, alcohol. Product: ester.
The Yamaguchi esterification is an organic reaction used to convert a carboxylic acid and an alcohol to an ester using triethylamine, the Yamaguchi reagent, and DMAP. The mechanism begins with deprotonation of the carboxylic acid by Et3N to form a carboxylate anion which then attacks the Yamaguchi reagent. The resultant acid anhydride get attacked by DMAP to form a better leaving group which is then displaced by the alcohol reagent. A final deprotonation step results in the ester product

Mechanism of the Yamaguchi esterification.
Rino Safrizal
Jejaring Kimia Updated at: November 15, 2015

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